Effective inhibition of thrombin by Rhipicephalus microplus serpin-15 (RmS-15) obtained in the yeast Pichia pastoris.

@article{Xu2016EffectiveIO,
  title={Effective inhibition of thrombin by Rhipicephalus microplus serpin-15 (RmS-15) obtained in the yeast Pichia pastoris.},
  author={Tao Xu and Ala E. Lew-Tabor and Manuel Rodr{\'i}guez-Valle},
  journal={Ticks and tick-borne diseases},
  year={2016},
  volume={7 1},
  pages={180-187}
}
The cattle tick (Rhipicephalus microplus) affects cattle industries in tropical and subtropical countries because it is the vector of babesiosis and anaplasmosis which constitutes a threat to the health of cattle. During blooding feeding, ticks secrete saliva containing a complex of bioactive molecules into the injured site to evade host's defensive responses. Serine protease inhibitors (serpins) are important anti-haemostatic molecules present in tick saliva that are necessary for a successful… CONTINUE READING