Effective induction of high-titer antibodies by viral vector vaccines

@article{Draper2008EffectiveIO,
  title={Effective induction of high-titer antibodies by viral vector vaccines},
  author={Simon J Draper and Anne C. Moore and Anna L. Goodman and Carole A. Long and Anthony A. Holder and Sarah C Gilbert and Fergal Hill and Adrian V S Hill},
  journal={Nature Medicine},
  year={2008},
  volume={14},
  pages={819-821}
}
Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus–poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant… CONTINUE READING