Effective incorporation of insulin in mucus permeating self-nanoemulsifying drug delivery systems.


The development of a novel, mucus permeating SNEDDS formulation for oral insulin delivery containing a hydrophobic ion pair of insulin/dimyristoyl phosphatidylglycerol (INS/DMPG) is presented. Three oil/surfactant/cosurfactant combinations and 27 weight ratios of oil, surfactant and cosurfactant for each combination were evaluated with the aid of ternary… (More)
DOI: 10.1016/j.ejpb.2015.04.013


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