Effective healing of diabetic skin wounds by using nonviral gene therapy based on minicircle vascular endothelial growth factor DNA and a cationic dendrimer.

@article{Kwon2012EffectiveHO,
  title={Effective healing of diabetic skin wounds by using nonviral gene therapy based on minicircle vascular endothelial growth factor DNA and a cationic dendrimer.},
  author={Min Jeong Kwon and Songhie An and Sunghyun Choi and Kihoon Nam and Hye Sook Jung and Chang Shin Yoon and Jung Hae Ko and Hye J Jun and Tae Kyoon Kim and Soo Jung Jung and Jeong Hwan Park and Yan Yi Lee and Jong-sang Park},
  journal={The journal of gene medicine},
  year={2012},
  volume={14 4},
  pages={272-8}
}
BACKGROUND The development of an efficient method to improve the wound healing process is urgently required for diabetic patients suffering a threat of limb amputations. Various growth factors have been proposed for treatment; however, more research still has to be carried out to maintain their curative effect. In the present study, we describe a simple nonviral gene therapy method for improving wound healing. METHODS Minicircle plasmid DNA encoding vascular endothelial growth factor (VEGF… CONTINUE READING

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