Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus.

@article{Motoi2000EffectiveGT,
  title={Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus.},
  author={Fuyuhiko Motoi and Makoto Sunamura and Liping Ding and Dan G Duda and Yoko Yoshida and Wei Zhang and Seiki Matsuno and Hirofumi Hamada},
  journal={Human gene therapy},
  year={2000},
  volume={11 2},
  pages={
          223-35
        }
}
Pancreatic cancer has a poor prognosis even when surgical treatment can be accomplished. Studies have demonstrated that pancreatic cancer is associated with various genetic abnormalities in oncogenes and tumor suppressor genes including p53. New therapeutic approaches for pancreatic cancer can be developed by targeting these genetic alterations. Adenovirus (Adv) lacking the 55-kDa E1B protein (E1B55K) replicates preferentially in p53-deficient cancer cells. We constructed E1B55K-deleted Adv… CONTINUE READING
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