Effective electrophoretic mobilities and charges of anti-VEGF proteins determined by capillary zone electrophoresis.

Abstract

Macromolecules such as therapeutic proteins currently serve an important role in the treatment of eye diseases such as wet age-related macular degeneration and diabetic retinopathy. Particularly, bevacizumab and ranibizumab have been shown to be effective in the treatment of these diseases. Iontophoresis can be employed to enhance ocular delivery of these… (More)
DOI: 10.1016/j.jpba.2010.12.027

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