Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in rats, dogs, and monkeys.

@article{Balani2002EffectiveDR,
  title={Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in rats, dogs, and monkeys.},
  author={Suresh K. Balani and Tong Zhu and Tian J. Yang and Zhi Yi Liu and Bing He and Frank W. H. Lee},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2002},
  volume={30 10},
  pages={1059-62}
}
1-Aminobenzotriazole (ABT) has been extensively used as a nonspecific inhibitor of cytochromes p450 (p450s) in animals for mechanistic studies, and antipyrine (AP) has been used as a probe for hepatic oxidative metabolic capacity determination in vivo. The method of use of ABT has been variable from lab to lab due largely to unknown pharmacokinetics of ABT itself and incomplete information on various p450s inhibited. The oral pharmacokinetic profiles of ABT were generated in rats, dogs, and… CONTINUE READING

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