Effective dose of granisetron for preventing postoperative emesis in children.

  title={Effective dose of granisetron for preventing postoperative emesis in children.},
  author={Yuriko Fujii and Hidenori Toyooka and Hiroyoshi Tanaka},
  journal={Canadian journal of anaesthesia = Journal canadien d'anesthesie},
  volume={43 7},
PURPOSE This study was to identify the minimum effective dose of granisetron, a selective 5-hydroxytryptamine type 3 receptor antagonist, to prevent postoperative vomiting in children who have undergone strabismus repair, tonsillectomy or tonsillectomy with adenoidectomy. METHODS In a randomized, double-blind fashion, 80 healthy children aged 4-10 yr were assigned to receive either placebo (saline) or granisetron in a dose of 20, 40 or 80 micrograms.kg-1 iv immediately following the induction… CONTINUE READING
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