Effective diminution of amniotic prostaglandin production by selective inhibitors of cyclooxygenase type 2.

@article{Sadovsky2000EffectiveDO,
  title={Effective diminution of amniotic prostaglandin production by selective inhibitors of cyclooxygenase type 2.},
  author={Yoel Sadovsky and David M. Q. Nelson and Louis J. Muglia and Gilad A. Gross and Katrina C. Harris and Alane Koki and Jaime L. Masferrer and Lisa M. Olson},
  journal={American journal of obstetrics and gynecology},
  year={2000},
  volume={182 2},
  pages={370-6}
}
OBJECTIVE Cyclooxygenase inhibitors are effective tocolytic agents, but significant adverse effects limit their use. We hypothesized that selective inhibitors of the isozyme cyclooxygenase 2 would effectively diminish labor-associated prostaglandin production. STUDY DESIGN We analyzed cyclooxygenase type 1 and 2 expression in amnion, chorion, decidua, and myometrium from laboring or nonlaboring women and tested the efficacy of selective cyclooxygenase 2 inhibition in diminishing prostaglandin… CONTINUE READING
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