Effective delivery with enhanced translational activity synergistically accelerates mRNA-based transfection.

@article{Zohra2007EffectiveDW,
  title={Effective delivery with enhanced translational activity synergistically accelerates mRNA-based transfection.},
  author={Fatema Tuj Zohra and Ezharul Hoque Chowdhury and Seiichi Tada and Takashi Hoshiba and Toshihiro Akaike},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={358 1},
  pages={373-8}
}
mRNA instead of DNA provides a new and attractive approach for gene therapy and genetic vaccination. Current technologies for mRNA delivery are based on cationic lipids with DOTAP being the most efficient one. We previously reported on the synthesis of an inorganic-organic hybrid carrier by embedding inorganic nano-particles of carbonate apatite onto liposomal carrier DOTAP and demonstrated its high transfection potency of luciferase mRNA both in mitotic and non-mitotic cells. Here we show that… CONTINUE READING
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