Effective antiplatelet therapy does not prolong transgenic pig to baboon cardiac xenograft survival.

@article{Schirmer2004EffectiveAT,
  title={Effective antiplatelet therapy does not prolong transgenic pig to baboon cardiac xenograft survival.},
  author={Johannes M Schirmer and David Fass and Guerard W Byrne and Henry Dale Tazelaar and John S. Logan and Christopher G A McGregor},
  journal={Xenotransplantation},
  year={2004},
  volume={11 5},
  pages={436-43}
}
BACKGROUND Microvascular thrombosis is a prominent characteristic of delayed xenograft rejection, therefore the effects of antiplatelet therapy with aspirin and clopidogrel on long-term cardiac xenograft function was investigated in a heterotopic pig-to-baboon cardiac transplant model. METHODS Donor hearts from human CD46 transgenic pigs were transplanted heterotopically to baboons. The recipients received immunosuppression that included tacrolimus, sirolimus, corticosteroids, anti-CD20… CONTINUE READING