Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.

@article{Yoshimura2001EffectiveAP,
  title={Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.},
  author={Sinichi Yoshimura and Jan Bondeson and Brian M. J. Foxwell and Fionula Mary Brennan and Marc Feldmann},
  journal={International immunology},
  year={2001},
  volume={13 5},
  pages={675-83}
}
Antigen presentation is a key rate-limiting step in the immune response. Dendritic cells (DC) are the most potent antigen-presenting cells for naive T cells, due to their high expression of MHC and co-stimulatory molecules, but little is known about the biochemical pathways that regulate this function. We here demonstrate that monocyte-derived mature DC can be infected with adenovirus at high efficiency (>95%) and that this procedure can be used to dissect out which pathways are essential for… CONTINUE READING
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