Effective anti-tumor responses induced by recombinant bacillus Calmette-Guérin vaccines based on different tandem repeats of MUC1 and GM-CSF.

@article{Yuan2009EffectiveAR,
  title={Effective anti-tumor responses induced by recombinant bacillus Calmette-Gu{\'e}rin vaccines based on different tandem repeats of MUC1 and GM-CSF.},
  author={Shi-Fang Yuan and Changhong Shi and Wei Han and Rui Ling and Nanlin Li and Ting Wang},
  journal={European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation},
  year={2009},
  volume={18 5},
  pages={416-23}
}
In this study, we constructed several novel breast cancer vaccines, Bacillus Calmette-Guérin (BCG)-MUC1 variable-number tandem repeats (VNTR) 1/4/8-CSF, that consist of BCG and express 1, 4, and 8 of the tandem repeats of MUC1 and human granulocyte-macrophage colony-stimulating factor (GM-CSF). The ability of the three recombinant BCG vaccines to inhibit breast cancer growth was observed in human (hu)-peripheral blood lymphocyte (PBL)-severe combined immunodeficient (SCID) mice. Prophylactic… CONTINUE READING

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