Effective and long-term control of EBV PTLD after transfer of peptide-selected T cells.

@article{Moosmann2010EffectiveAL,
  title={Effective and long-term control of EBV PTLD after transfer of peptide-selected T cells.},
  author={Andreas Moosmann and Iris Bigalke and J. Tischer and Leah Schirrmann and Julitta Kasten and Stefanie Tippmer and Marina Leeping and Dusan Prevalsek and Gundula Jaeger and Georg J Ledderose and Josef Mautner and Wolfgang Hammerschmidt and Dolores J. Schendel and H. Kolb},
  journal={Blood},
  year={2010},
  volume={115 14},
  pages={2960-70}
}
Posttransplantation lymphoproliferative disease (PTLD) associated with Epstein-Barr virus (EBV) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation. PTLD is efficiently prevented by adoptive transfer of EBV-specific T cells from the donor. To make EBV-specific T cells available in urgent clinical situations, we developed a rapid protocol for their isolation by overnight stimulation of donor blood cells with peptides derived from 11 EBV antigens… CONTINUE READING
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