Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice.

@article{Huber1998EffectiveAL,
  title={Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice.},
  author={Magdalena Huber and Emma M. Timms and Tak W Mak and Martin Roellinghoff and Michael Lohoff},
  journal={Infection and immunity},
  year={1998},
  volume={66 8},
  pages={3968-70}
}
The results of earlier investigations that tested whether CD8(+) T cells are required in the defense against Leishmania major have been inconsistent. We used CD8-deficient mice to directly address this issue. After primary infection with L. major, CD8-deficient mice controlled the infection for over 1 year and mounted strong T helper 1 cell responses. Thus, CD8(+) T cells are not required for the long-term control of a primary infection with L. major. 

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