Effective Treatment of Heavy Menstrual Bleeding With Estradiol Valerate and Dienogest: A Randomized Controlled Trial

@article{Jensen2011EffectiveTO,
  title={Effective Treatment of Heavy Menstrual Bleeding With Estradiol Valerate and Dienogest: A Randomized Controlled Trial},
  author={Jeffrey T Jensen and Susanne Parke and Uwe Mellinger and Andrea Machlitt and Ian Stewart Fraser},
  journal={Obstetrics \& Gynecology},
  year={2011},
  volume={117},
  pages={777-787}
}
OBJECTIVE: To estimate the efficacy of a fixed estrogen step-down and progestin step-up 28-day estradiol (E2) valerate and dienogest oral contraceptive regimen in women with heavy menstrual bleeding, prolonged menstrual bleeding, or heavy and prolonged menstrual bleeding without organic pathology. METHODS: This double-blind, placebo-controlled study randomized women aged 18 years or older with prolonged, frequent, or heavy menstrual bleeding, objectively confirmed during a 90-day run-in phase… Expand
Normalization of blood loss in women with heavy menstrual bleeding treated with an oral contraceptive containing estradiol valerate/dienogest.
TLDR
E₂V/DNG is highly effective for the treatment of HMB and is associated with a high rate of treatment success, according to a pooled analysis of data from two identically designed randomized, placebo-controlled, multiple center studies conducted in Europe, Australia and North America. Expand
Novel oral contraceptive for heavy menstrual bleeding: estradiol valerate and dienogest
TLDR
Use of E2V/DNG for six months has led to significant reductions in heavy menstrual bleeding with an average 65% reduction in mean blood loss, and significant improvements in hematologic indicators have been shown. Expand
Effective treatment of heavy and/or prolonged menstrual bleeding without organic cause: pooled analysis of two multinational, randomised, double-blind, placebo-controlled trials of oestradiol valerate and dienogest
TLDR
E2V/DNG was more effective than placebo in reducing MBL in women with heavy and/or prolonged menstrual bleeding without organic pathology, and the greatest reduction was achieved at the first withdrawal bleed after treatment initiation. Expand
Use of combined oral contraceptives for the management of heavy menstrual bleeding
TLDR
A new COC containing estradiol valerate and dienogest was compared with placebo in a randomized clinical trial that included women with objectively confirmed HMB in whom blood loss was measured using the alkaline hematin method. Expand
Use of mixed-treatment-comparison methods in estimating efficacy of treatments for heavy menstrual bleeding
TLDR
LNG-IUS and endometrial ablation are very efficacious in treating HMB and yielded useful insights on using MTC in sparse evidence networks. Expand
Nonsurgical Management of Heavy Menstrual Bleeding: A Systematic Review
TLDR
For the reduction in mean blood loss in women with heavy menstrual bleeding presumedsecondary to abnormal uterine bleeding presumed secondary to endometrial dysfunction, the levonorgestrel intrauterine system was superior to combined OCPs and NSAIDs and antifibrinolytics were superior to NSAIDs for menstrual bleeding reduction. Expand
Combined hormonal contraceptives for heavy menstrual bleeding.
TLDR
A review of randomised controlled trials of the use of COCP or CVR compared with no treatment, placebo, or other medical therapies for women with HMB and regular menstrual cycles found insufficient evidence to determine whether the C OCP reduced MBL when compared to NSAIDs. Expand
Long-Term Evaluation of Safety and Health-Related Quality of Life in Women with Heavy Menstrual Bleeding Treated with Oral Tranexamic Acid
TLDR
Improvements in generic and disease-specific HRQoL measures were evident during the first treatment cycle and were maintained throughout the 15 cycles of measurement for most domains and long-term TA treatment was well tolerated and improved measures of HRZoL in women with cyclic HMB. Expand
How I treat heavy menstrual bleeding associated with anticoagulants.
TLDR
For women who require long-term anticoagulation, a levonorgestrel intrauterine system, tranexamic acid (during menstrual flow), high-dose progestin-only therapy, or combined hormonal contraceptives are effective for controlling HMB. Expand
Estradiol Valerate and Dienogest: A Novel Four-Phasic Oral Contraceptive Pill Effective for Pregnancy Prevention and Treatment of Heavy Menstrual Bleeding
Estradiol valerate and dienogest have been combined to create a novel four-phasic oral contraceptive pill effective for both pregnancy prevention and treatment of heavy menstrual bleeding. ThisExpand
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