Effective Prevention of Liver Fibrosis by Liver-targeted Hydrodynamic Gene Delivery of Matrix Metalloproteinase-13 in a Rat Liver Fibrosis Model

@article{Abe2016EffectivePO,
  title={Effective Prevention of Liver Fibrosis by Liver-targeted Hydrodynamic Gene Delivery of Matrix Metalloproteinase-13 in a Rat Liver Fibrosis Model},
  author={H. Abe and K. Kamimura and Yuji Kobayashi and M. Ohtsuka and H. Miura and R. Ohashi and Takeshi Yokoo and T. Kanefuji and T. Suda and M. Tsuchida and Y. Aoyagi and Guisheng Zhang and D. Liu and S. Terai},
  journal={Molecular Therapy. Nucleic Acids},
  year={2016},
  volume={5}
}
  • H. Abe, K. Kamimura, +11 authors S. Terai
  • Published 2016
  • Biology, Medicine
  • Molecular Therapy. Nucleic Acids
  • Liver fibrosis is the final stage of liver diseases that lead to liver failure and cancer. While various diagnostic methods, including the use of serum marker, have been established, no standard therapy has been developed. The objective of this study was to assess the approach of overexpressing matrix metalloproteinase-13 gene (MMP13) in rat liver to prevent liver fibrosis progression. A rat liver fibrosis model was established by ligating the bile duct, followed by liver-targeted hydrodynamic… CONTINUE READING
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