Effective MicroPET imaging of brain 5‐HT1A receptors in rats with [18F]MeFWAY by suppression of radioligand defluorination

@article{Choi2012EffectiveMI,
  title={Effective MicroPET imaging of brain 5‐HT1A receptors in rats with [18F]MeFWAY by suppression of radioligand defluorination},
  author={Jae Yong Choi and Chul Hoon Kim and Tae Joo Jeon and Byoung Soo Kim and Chi Hoon Yi and Kwang Sun Woo and Young Beom Seo and Sang Jin Han and KyeongMin Kim and Dae Ik Yi and Minkyung Lee and Dong Goo Kim and Jung Young Kim and Kyochul Lee and Tae-Hyun Choi and Gwang Il An and Young Hoon Ryu},
  journal={Synapse},
  year={2012},
  volume={66}
}
  • J. ChoiC. Kim Y. Ryu
  • Published 1 December 2012
  • Biology, Medicine, Chemistry
  • Synapse
Introduction: [18F]MeFWAY has been developed for imaging the serotonin 1A receptors in the brain. The purpose of this study were to verify the metabolic stability of [18F]MeFWAY, to measure the degree of defluorination of [18F]MeFWAY in vivo, to investigate methods of inhibition of defluorination of [18F]MeFWAY, and to assess the efficacy of [18F]MeFWAY in rat brains in vivo. Methods: MicroPET experiments in rats were conducted to confirm the distribution of radioactivity in the brain… 

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