Effective Immunochemotherapy of CALLAT y+ Human Pre-B Acute Lymphoblastic Leukemia in Mice With Severe Combined Immunodeficiency Using B43 (anti-CD19) Pokeweed Antiviral Protein Immunotoxin Plus Cyclophosphamide

Abstract

A highly aggressive human CALLA+Cp+ pre-B acute lymphoblastic leukemia (ALL) cell line (NALM-6-UM1) causes disseminated and invariably fatal leukemia in CB.17 mice with severe combined immunodeficiency (SCID). We used this SClD mouse model of human pre-B ALL to evaluate and compare, in a total of 434 SClD mice, the antileukemic efficacy of 843 (anti-CD19… (More)

Topics

10 Figures and Tables

Cite this paper

@inproceedings{Finnegan2003EffectiveIO, title={Effective Immunochemotherapy of CALLAT y+ Human Pre-B Acute Lymphoblastic Leukemia in Mice With Severe Combined Immunodeficiency Using B43 (anti-CD19) Pokeweed Antiviral Protein Immunotoxin Plus Cyclophosphamide}, author={Dale Finnegan and Lisa Tuel-Ahlgren and Carlos J. Manivel and Roland Gunther}, year={2003} }