Effective Chikungunya Virus-like Particle Vaccine Produced in Insect Cells

@inproceedings{Metz2013EffectiveCV,
  title={Effective Chikungunya Virus-like Particle Vaccine Produced in Insect Cells},
  author={Stefan W Metz and Joy Gardner and Corinne Geertsema and Thuy Trong Le and Lucas Y. H. Goh and Just M. Vlak and Andreas Suhrbier and Gorben P Pijlman},
  booktitle={PLoS neglected tropical diseases},
  year={2013}
}
The emerging arthritogenic, mosquito-borne chikungunya virus (CHIKV) causes severe disease in humans and represents a serious public health threat in countries where Aedes spp mosquitoes are present. This study describes for the first time the successful production of CHIKV virus-like particles (VLPs) in insect cells using recombinant baculoviruses. This well-established expression system is rapidly scalable to volumes required for epidemic responses and proved well suited for processing of… CONTINUE READING