Effect-site half-time for burst suppression is longer than for hypnosis during anaesthesia with sevoflurane.

@article{Kennedy2008EffectsiteHF,
  title={Effect-site half-time for burst suppression is longer than for hypnosis during anaesthesia with sevoflurane.},
  author={R. Ross Kennedy and Christine Minto and A Seethepalli},
  journal={British journal of anaesthesia},
  year={2008},
  volume={100 1},
  pages={
          72-7
        }
}
BACKGROUND The relationship between measures of drug effect such as bispectral index (BIS) and end-tidal (ET) levels of anaesthetic agents is described by the 'effect site equilibrium half-time', t(1/2)(ke0). There are limited data available on sevoflurane t(1/2)(ke0) during routine anaesthesia and surgery. Preliminary observations suggested t(1/2)(ke0) for the degree of hypnosis as estimated by BIS is different from that for burst suppression of the electroencephalograph, occurring at 'deep… CONTINUE READING