Effect site concentration during propofol TCI sedation: a comparison of sedation score with two pharmacokinetic models.

@article{Barakat2007EffectSC,
  title={Effect site concentration during propofol TCI sedation: a comparison of sedation score with two pharmacokinetic models.},
  author={A R Barakat and Neil Sutcliffe and Matthias Schwab},
  journal={Anaesthesia},
  year={2007},
  volume={62 7},
  pages={661-6}
}
Target controlled infusion (TCI) pumps function using a programme based on a pharmacokinetic/pharmacodynamic model. We compared the Marsh and Schnider models to find out which better correlates with the clinically observed effect of propofol as assessed by the Observer Assessment of Alertness/Sedation (OAAS) score and the Bispectral index. We assessed the sedation score and Bispectral index score in 40 un-premedicated patients undergoing surgical procedures under spinal anaesthesia with… CONTINUE READING

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