Effect on tumor cells of blocking survival response to glucose deprivation.

  title={Effect on tumor cells of blocking survival response to glucose deprivation.},
  author={H S Park and Akihiro Tomida and Shigeo Sato and Yoshinori Tsukumo and Jisoo Yun and Takao Yamori and Yoichi Hayakawa and Takashi Tsuruo and Kazuo Shin-Ya},
  journal={Journal of the National Cancer Institute},
  volume={96 17},
BACKGROUND Glucose deprivation, a feature of poorly vascularized solid tumors, activates the unfolded protein response (UPR), a stress-signaling pathway, in tumor cells. We recently isolated a novel macrocyclic compound, versipelostatin (VST), that inhibits transcription from the promoter of GRP78, a gene that is activated as part of the UPR. We examined the effect of VST on the UPR induced by glucose deprivation or other stressors and on tumor growth in vivo. METHODS Human colon cancer HT-29… CONTINUE READING


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