Effect on the peripheral nervous system of the short-term intravenous administration of paclitaxel in the rat.

@article{Cavaletti1997EffectOT,
  title={Effect on the peripheral nervous system of the short-term intravenous administration of paclitaxel in the rat.},
  author={Guido Cavaletti and Ennio Cavalletti and P Montaguti and Norberto Oggioni and O De Negri and Giovanni Tredici},
  journal={Neurotoxicology},
  year={1997},
  volume={18 1},
  pages={137-45}
}
The effectiveness of paclitaxel (Taxol) in the treatment of different tumors is well-known but, on the other hand, there is little information regarding its neurotoxicity and the mechanism(s) underlying this potentially severe side effect. In this study, using behavioral, neurophysiological, morphological and morphometric methods, we evaluated the effect of intravenous administration of paclitaxel on the rat nervous system. After 2 pilot studies, 40 female Wistar rats were treated with… CONTINUE READING
48 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 48 extracted citations

Similar Papers

Loading similar papers…