Effect on risk of anencephaly of gene-nutrient interactions between methylenetetrahydrofolate reductase C677T polymorphism and maternal folate, vitamin B12 and homocysteine profile.

@article{Lacasaa2012EffectOR,
  title={Effect on risk of anencephaly of gene-nutrient interactions between methylenetetrahydrofolate reductase C677T polymorphism and maternal folate, vitamin B12 and homocysteine profile.},
  author={Marina Lacasa{\~n}a and Julia Blanco-Mu{\~n}oz and V{\'i}ctor Hugo Borja-Aburto and Clemente Aguilar-Gardu{\~n}o and Miguel Rodr{\'i}guez-Barranco and Jos{\'e} Alfredo Sierra-Ram{\'i}rez and Carlos Galav{\'i}z-Hern{\'a}ndez and Beatriz Gonz{\'a}lez-Alzaga and Ricardo Juan Garc{\'i}a-Cavazos},
  journal={Public health nutrition},
  year={2012},
  volume={15 8},
  pages={
          1419-28
        }
}
OBJECTIVE To evaluate the effects on anencephaly risk of the interaction between the maternal profile of folate, vitamin B12 and homocysteine and the 677C→T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR). DESIGN Case-control study paired (1:1) on maternity clinic, date of birth and state of residence. Cases of anencephaly were identified using the Registry of the Mexican Neural Tube Defect Epidemiological Surveillance System. Case and control mothers were… CONTINUE READING
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