Effect on polyomavirus T-antigen function of mutations in a conserved leucine-rich segment of the DnaJ domain.

Abstract

The N-terminal part of the mouse polyomavirus T antigens contains a highly conserved segment (-LLELLKL-), including amino acid residues 13 to 19. The sequence motif is predicted to form alpha helix I in the DnaJ domain of the T antigens. Four mutants with conservative substitutions of amino acid residues 13 and 14 were constructed. Of the four substitutions… (More)

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Cite this paper

@article{Li2001EffectOP, title={Effect on polyomavirus T-antigen function of mutations in a conserved leucine-rich segment of the DnaJ domain.}, author={Hoaxia Li and Karin S{\"{o}derb{\"a}rg and Hamid Houshmand and Zhenyu You and G{\"{o}ran Magnusson}, journal={Journal of virology}, year={2001}, volume={75 5}, pages={2253-61} }