[Effect, on kidney structure, of the use of antitumor preparations combined with diacarb and furosemide].

Abstract

It has been shown in experiments on rats with transplanted sarcoma 45 that cyclophosphane (10 mg/kg) and 6-mercaptopurine (25 mg/kg) produced hemodynamic changes in the kidneys, as well as swelling of the endothelium of the glomerular capillaries and of the epithelium of the tubules, and focal interstitial fibrosis. Concurrent administration of antineoplastic drugs with diacarb (200 mg/kg) or furosemide (50 mg/kg) returned the hemodynamics to normal and reduced nephrotoxicity of the antineoplastic drugs used.

Cite this paper

@article{Arefeva1982EffectOK, title={[Effect, on kidney structure, of the use of antitumor preparations combined with diacarb and furosemide].}, author={A K Aref'eva and V. A. Rykov}, journal={Farmakologiia i toksikologiia}, year={1982}, volume={45 5}, pages={78-80} }