Effect of zinc pyridinethione on the tissue disposition of nickel and cadmium in mice.

@article{Jasim1986EffectOZ,
  title={Effect of zinc pyridinethione on the tissue disposition of nickel and cadmium in mice.},
  author={S Jasim and Hans Tj{\"a}lve},
  journal={Acta pharmacologica et toxicologica},
  year={1986},
  volume={59 3},
  pages={204-8}
}
Oral administration of zinc pyridinethione together with 63Ni2+ or 109Cd2+ to mice resulted in increased levels of these metals in several tissues in comparison with animals given the metals alone. The disposition of the 63Ni2+ was affected more than the disposition of the 109Cd2+. Increased urinary excretion of the metals was also induced by the zinc pyridinethione. Determinations of chloroform:water partition coefficients showed that lipophilic complexes are formed at equilibrations between… CONTINUE READING

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