Effect of zearalenone on early pregnancy in guinea pigs.

  title={Effect of zearalenone on early pregnancy in guinea pigs.},
  author={G. G. Long and Mark A. Diekman},
  journal={American journal of veterinary research},
  volume={50 8},
Female guinea pigs were tested to determine whether they could serve as a model of zearalenone (ZEN) toxicosis during early pregnancy, as observed in domestic swine. Only 1 of 4 female guinea pigs that were given 21 mg of ZEN/kg of body weight orally during the first 8 days after mating was pregnant when examined 22 days after mating. Guinea pigs that were given 7 or 14 mg of ZEN/kg had normal fetal development. Serum concentrations of progesterone were less than 12 ng/ml in all guinea pigs 8… CONTINUE READING