Effect of xanthine derivatives on hippocampal long-term potentiation.

  title={Effect of xanthine derivatives on hippocampal long-term potentiation.},
  author={Yoshino Tanaka and Minori Sakurai and Makoto Goto and Shinji Hayashi},
  journal={Brain research},
  volume={522 1},
The effect of the structurally similar xanthine derivatives, propentofylline, pentoxifylline and theophylline, on long-term potentiation (LTP) recorded in CA3 of hippocampal slices of guinea pigs was investigated. A concentration-dependent increase in the amplitude of the population spike of CA3 pyramidal neurons was evoked by bath application of propentofylline and theophylline with a threshold concentration of 10 microM. This increase returned to the control level after washout for 20-30 min… CONTINUE READING

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