Effect of wnt-1 and related proteins on gap junctional communication in Xenopus embryos.

@article{Olson1991EffectOW,
  title={Effect of wnt-1 and related proteins on gap junctional communication in Xenopus embryos.},
  author={David J. Olson and Jan L Christian and Randall T. Moon},
  journal={Science},
  year={1991},
  volume={252 5009},
  pages={1173-6}
}
The proto-oncogene wnt-1 (previously referred to as int-1) is thought to be important in embryonic pattern formation although its mechanisms of action are unknown. Premature and increased expression of the Wnt-1 protein, achieved by injection of synthetic wnt-1 RNA into fertilized Xenopus eggs, enhanced gap junctional communication between ventral cells of the developing embryo. This result is consistent with the hypothesis that Wnt proteins activate a receptor-mediated signal transduction… CONTINUE READING

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