Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome.

@article{Hyun2002EffectOW,
  title={Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome.},
  author={Dong-Hoon Hyun and Moonhee Lee and Nobutaka Hattori and Shin-ichiro Kubo and Yoshikuni Mizuno and Barry Halliwell and Peter Jenner},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 32},
  pages={28572-7}
}
Mutations in Parkin (a ubiquitin protein ligase) are involved in autosomal recessive juvenile parkinsonism, but it is not known how they cause nigral cell death. We examined the effect of Parkin overexpression on cellular levels of oxidative damage, antioxidant defenses, nitric oxide production, and proteasomal enzyme activity. Increasing expression of Parkin by gene transfection in NT-2 and SK-N-MC cells led to increased proteasomal activity, decreased levels of protein carbonyls, 3… CONTINUE READING

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