Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects.

@article{Houmard2002EffectOW,
  title={Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects.},
  author={Joseph A. Houmard and Charles J. Tanner and Chunli Yu and Paul R. G. Cunningham and Walter J. Pories and Kenneth G Macdonald and Gerald I Shulman},
  journal={Diabetes},
  year={2002},
  volume={51 10},
  pages={2959-63}
}
Increases in intramyocellular long-chain fatty acyl-CoAs (LCACoA) have been implicated in the pathogenesis of insulin resistance in skeletal muscle. To test this hypothesis, we measured muscle (vastus lateralis) LCACoA content and insulin action in morbidly obese patients (n = 11) before and after weight loss (gastric bypass surgery). The intervention… CONTINUE READING