Effect of water-soluble polymers on the physical stability of aqueous polymeric dispersions and their implications on the drug release from coated pellets.

@article{Dashevsky2010EffectOW,
  title={Effect of water-soluble polymers on the physical stability of aqueous polymeric dispersions and their implications on the drug release from coated pellets.},
  author={Andrei Dashevsky and Abid Riaz Ahmed and Jorge Mota and Muhammad Irfan and Karl Kolter and Roland A Bodmeier},
  journal={Drug development and industrial pharmacy},
  year={2010},
  volume={36 2},
  pages={152-60}
}
PURPOSE To investigate the physical stability and drug release-related properties of the aqueous polymer dispersions Kollicoat((R)) SR 30 D and Aquacoat((R)) ECD (an ethylcellulose-based dispersion) in the presence water-soluble polymers (pore formers) with special attention to the potential flocculation of the polymer dispersions. METHODS A precise characterization of the flocculation phenomena in undiluted samples was monitored with turbidimetric measurements using the Turbiscan Lab-Expert… CONTINUE READING