Effect of vorapaxar on myocardial infarction in the thrombin receptor antagonist for clinical event reduction in acute coronary syndrome (TRA·CER) trial.

@article{Leonardi2013EffectOV,
  title={Effect of vorapaxar on myocardial infarction in the thrombin receptor antagonist for clinical event reduction in acute coronary syndrome (TRA·CER) trial.},
  author={Sergio Leonardi and Pierluigi Tricoci and Harvey Douglas White and Priscilla W. Armstrong and Zhen Huang and Lars Wallentin and Philip Aylward and David J Moliterno and Frans J J Van De Werf and Edmond Chen and Lu{\'i}s Augusto Provid{\^e}ncia and Jan Erik Nordrehaug and Claes Held and John T. Strony and Tyrus L Rorick and Robert A. Harrington and Kenneth W. Mahaffey},
  journal={European heart journal},
  year={2013},
  volume={34 23},
  pages={
          1723-31
        }
}
AIMS The TRA·CER trial compared vorapaxar, a novel platelet protease-activated receptor (PAR)-1 antagonist, with placebo in 12 944 patients with high-risk non-ST-segment elevation acute coronary syndromes (NSTE ACS). In this analysis, we explored the effect of vorapaxar on myocardial infarction (MI). METHODS AND RESULTS A blinded, independent central endpoint adjudication committee prospectively defined and classified MI according to the universal MI definition, including peak cardiac marker… CONTINUE READING

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