Effect of volume loading with 1 liter intravenous infusions of 0.9% saline, 4% succinylated gelatine (Gelofusine) and 6% hydroxyethyl starch (Voluven) on blood volume and endocrine responses: a randomized, three-way crossover study in healthy volunteers.

@article{Lobo2010EffectOV,
  title={Effect of volume loading with 1 liter intravenous infusions of 0.9% saline, 4% succinylated gelatine (Gelofusine) and 6% hydroxyethyl starch (Voluven) on blood volume and endocrine responses: a randomized, three-way crossover study in healthy volunteers.},
  author={Dileep N Lobo and Zeno Stanga and Mark M. Aloysius and Catherine Wicks and Quentin M Nunes and Katharine Ingram and Lorenz Risch and Simon P Allison},
  journal={Critical care medicine},
  year={2010},
  volume={38 2},
  pages={464-70}
}
OBJECTIVE To study the changes in blood volume and hormones controlling sodium and water homeostasis after infusions of 0.9% saline, Gelofusine (4% succinylated gelatin in 0.7% saline, weight-average molecular weight 30 kD), and Voluven (6% hydroxyethyl starch in 0.9% saline, weight-average molecular weight 130 kD) in healthy volunteers. DESIGN Randomized, three-way crossover study. SETTING University teaching hospital. SUBJECTS Ten healthy adult male volunteers. INTERVENTIONS… CONTINUE READING
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