Effect of volatile anesthetics on the force-frequency relation in human ventricular myocardium: the role of the sarcoplasmic reticulum calcium-release channel.

@article{Schotten2001EffectOV,
  title={Effect of volatile anesthetics on the force-frequency relation in human ventricular myocardium: the role of the sarcoplasmic reticulum calcium-release channel.},
  author={Ulrich Schotten and Maura Greiser and V Braun and C Karlein and Friedrich Albert Schoendube and Peter Hanrath},
  journal={Anesthesiology},
  year={2001},
  volume={95 5},
  pages={
          1160-8
        }
}
BACKGROUND In human ventricular myocardium, contractile force increases at higher stimulation frequencies (positive force-frequency relation). In failing hearts, the force-frequency relation (FFR) is negative. Data on the effect of volatile anesthetics on FFR are very limited. METHODS The authors obtained left ventricular tissue from 18 explanted hearts from patients undergoing cardiac transplantation and tissue of 8 organ donors. The negative inotropic effect of halothane, isoflurane, and… CONTINUE READING