Effect of vitamin K3 on the first-pass elimination of propranolol in the rat.

@article{Ishida1985EffectOV,
  title={Effect of vitamin K3 on the first-pass elimination of propranolol in the rat.},
  author={Ryozo Ishida and T. Usui and Yasutsugu Fukushima and Shoichi Fujita and T. Suzuki},
  journal={Journal of pharmaceutical sciences},
  year={1985},
  volume={74 5},
  pages={
          578-81
        }
}
The effect of vitamin K3, which inhibits electron transfer from NADPH to cytochrome P-450 via cytochrome c reductase, on the metabolism of propranolol was studied in the rat in vitro and in vivo. For in vitro experiments using rat liver microsomes, the metabolism of propranolol was inhibited by vitamin K3. For in vivo experiments, the area under the blood concentration-time curve and the maximum concentration of propranolol were markedly increased following intraportal infusion of propranolol… 
2 Citations
In‐vitro biotransformation of antipyrine, lignocaine and propranolol in the liver of rats with turpentine‐induced inflammation
TLDR
The changes in drug disposition seen after turpentine‐induced inflammation, could be due in part to a change in hepatic enzymatic activity.
Method for chronic portal vein infusion in unrestrained rats.

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