Effect of vitamin K on bone mineral density and fractures in adults: an updated systematic review and meta-analysis of randomised controlled trials

@article{Mott2019EffectOV,
  title={Effect of vitamin K on bone mineral density and fractures in adults: an updated systematic review and meta-analysis of randomised controlled trials},
  author={A. Mott and T. Bradley and Kath Wright and E. S. Cockayne and M. Shearer and J. Adamson and S. Lanham-New and D. Torgerson},
  journal={Osteoporosis International},
  year={2019},
  pages={1-17}
}
SummaryVitamin K may affect bone mineral density and fracture incidence. Since publication of a previous systematic review the integrity of some of the previous evidence has been questioned and further trials have been published. Therefore an update to the systematic review was required.IntroductionThis systematic review was designed to assess the effectiveness of oral vitamin K supplementation for increasing bone mineral density and reducing fractures in adults.MethodsMEDLINE, EMBASE, CENTRAL… Expand
The efficacy and safety of menatetrenone in the management of osteoporosis: a systematic review and meta-analysis of randomized controlled trials
TLDR
Menatetrenone significantly decreases ucOC and might improve lumbar BMD in osteoporotic patients, however, its benefit in fracture risk control is uncertain. Expand
Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2
TLDR
Six months vitamin K supplementation did not halt progression of arterial calcification or decline of BMD in patients with DM2 and CVD, and future clinical trials may want to pre-select patients with very low vitamin K status and longer follow-up time might be warranted. Expand
Correction to Effect of vitamin K on bone mineral density and fractures in adults: an updated systematic review and meta-analysis of randomised controlled trials
TLDR
An adjustment is issued to all meta-analysis estimates that contained this work within the systematic review of Yamaguchi Osteoporosis Prevention Study conducted by Ishida and Kawai. Expand
Serum vitamin K1 (phylloquinone) is associated with fracture risk and hip strength in post-menopausal osteoporosis: a cross-sectional study.
TLDR
The data suggest that the positive effect of vitamin K on fracture risk may be related to its effects on bone strength, and higher concentrations of serum vitamin K1 may be requited for vitamin K's skeletal effects compared to coagulation. Expand
Nutrients and Dietary Patterns Related to Osteoporosis
TLDR
Although some dietary patterns seem to have beneficial effects, more studies are needed to fully elucidate the true influence of diet on bone fragility and the available scientific evidence for the effects of the main dietary patterns on bone health is evaluated. Expand
Associations of serum vitamins levels with bone mineral density in the different race-ethnicities US adults
TLDR
Elevated serum folate, vitamins A and C levels were associated with a higher BMD and sex and race/ ethnicity modified the associations of serum vitamins levels with BMD. Expand
Circulating Alpha-Tocopherol Levels, Bone Mineral Density, and Fracture: Mendelian Randomization Study
TLDR
A Mendelian randomization investigation of the associations of circulating α-tocopherol with estimated bone mineral density (eBMD) using heel ultrasound and fractures strengthens a causal link between increased circulate α-ocopherol and greater BMD. Expand
Nutritional Supplements and Skeletal Health
TLDR
The effect size of nutrient interventions are relatively small, requiring large sample sizes for trials with bone outcomes, may be difficult to blind, and the impact of supplementation may depend on baseline intake, however, nutrition is the only intervention that can be implemented life long and on a population wide basis. Expand
Calcium, vitamin D, vitamin K2, and magnesium supplementation and skeletal health.
TLDR
Data suggest that VitK2 supplementation might improve bone quality and reduce fracture risk in osteoporotic patients, potentially enhancing the efficacy of Ca ± vitD and Mg supplementation, but data regarding the effectiveness of vitK2 and MG supplementation on bone are inconclusive. Expand
The effects of vitamin K-rich green leafy vegetables on bone metabolism: A 4-week randomised controlled trial in middle-aged and older individuals
TLDR
In middle-aged healthy men and women, an easily achieved increase in dietary intake of vitamin K1-rich green leafy vegetables substantially reduces serum tOC and ucOC suggesting increased entry of OC into bone matrix, where it may improve the material property of bone. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 80 REFERENCES
Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
TLDR
This systematic review suggests that supplementation with phytonadione and menaquinone-4 reduces bone loss and in the case of the latter, there is a strong effect on incident fractures among Japanese patients. Expand
Calcium intake and bone mineral density: systematic review and meta-analysis
TLDR
Increasing calcium intake from dietary sources or by taking calcium supplements produces small non-progressive increases in BMD, which are unlikely to lead to a clinically significant reduction in risk of fracture. Expand
The efficacy and safety of menatetrenone in the management of osteoporosis: a systematic review and meta-analysis of randomized controlled trials
TLDR
Menatetrenone significantly decreases ucOC and might improve lumbar BMD in osteoporotic patients, however, its benefit in fracture risk control is uncertain. Expand
Vitamin K supplementation does not significantly impact bone mineral density and biochemical markers of bone in pre- and perimenopausal women.
TLDR
Six months of 600 microg/d vitamin K(1) supplementation did not improve regional BMD and biochemical markers of bone formation in this group of pre- and perimenopausal women. Expand
Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials
TLDR
The hypothesis that vitamin K2 plays kind of a role in the maintenance and improvement of vertebral BMD and the prevention of fractures in postmenopausal women with osteoporosis seemed to support. Expand
Effect of vitamin K supplementation on bone loss in elderly men and women.
TLDR
Phylloquinone supplementation in a dose attainable in the diet does not confer any additional benefit for bone health at the spine or hip when taken with recommended amounts of calcium and vitamin D. Expand
Vitamin K Supplementation in Postmenopausal Women with Osteopenia (ECKO Trial): A Randomized Controlled Trial
TLDR
Daily 5 mg of vitamin K1 supplementation for 2 to 4 y does not protect against age-related decline in BMD, but may protect against fractures and cancers in postmenopausal women with osteopenia. Expand
Vitamin K2 (Menatetrenone) Effectively Prevents Fractures and Sustains Lumbar Bone Mineral Density in Osteoporosis
TLDR
It is suggested thatitamin K2 treatment effectively prevents the occurrence of new fractures, although the vitamin K2–treated group failed to increase in LBMD. Expand
Vitamin K intake and the risk of fractures
TLDR
It is suggested that higher dietary vitamin K intake may moderately decrease the risk of fractures. Expand
Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial
TLDR
MK-7 taken as Natto over 1 year reduced serum levels of ucOC but did not influence bone loss rates in early menopausal women. Expand
...
1
2
3
4
5
...