Effect of vitamin E on prothrombin levels in warfarin-induced vitamin K deficiency.

@article{Corrigan1981EffectOV,
  title={Effect of vitamin E on prothrombin levels in warfarin-induced vitamin K deficiency.},
  author={J J Corrigan and L L Ulfers},
  journal={The American journal of clinical nutrition},
  year={1981},
  volume={34 9},
  pages={1701-5}
}
Rats rendered lightly vitamin K deficient with warfarin (0.01 mg/100 g, IP) and given the equivalent of 1000 units of vitamin E/kg IM for 7 days, showed a marked reduction in functional factor II activity, but normal factor II levels using Echis venom on coagulation analysis. In 12 humans receiving warfarin, vitamin E was administered in doses of 100 or 400 units/day orally for 4 wk. The results in these patients showed no significant change in the prothrombin time, factor II coagulant activity… CONTINUE READING