Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial.

@article{Dysken2014EffectOV,
  title={Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial.},
  author={Maurice W. Dysken and Mary C Sano and Sanjay Asthana and Julia E. Vertrees and Muralidhar Pallaki and M. D. Hern{\'a}ndez Llorente and Susan Love and Gerard D. Schellenberg and John Riley McCarten and Julie E Malphurs and Susana Prieto and Peijun Chen and David J. Loreck and George Trapp and Rajbir S Bakshi and Jacobo E. Mintzer and Judith L. Heidebrink and Ana Vidal-Cardona and Lillian M Arroyo and Angel R Cruz and Sally Zachariah and Neil W. Kowall and Mohit P. Chopra and Suzanne Craft and Stephen M. Thielke and Carolyn L. Turvey and Catherine L Woodman and Kimberly A Monnell and Kimberly A Gordon and Julie Tomaska and Yoav Segal and Peter Peduzzi and Peter Guarino},
  journal={JAMA},
  year={2014},
  volume={311 1},
  pages={33-44}
}
IMPORTANCE Although vitamin E and memantine have been shown to have beneficial effects in moderately severe Alzheimer disease (AD), evidence is limited in mild to moderate AD. OBJECTIVE To determine if vitamin E (alpha tocopherol), memantine, or both slow progression of mild to moderate AD in patients taking an acetylcholinesterase inhibitor. DESIGN, SETTING, AND PARTICIPANTS Double-blind, placebo-controlled, parallel-group, randomized clinical trial involving 613 patients with mild to… CONTINUE READING