Effect of vitamin E TPGS on immune response to nasally delivered diphtheria toxoid loaded poly(caprolactone) microparticles.

@article{Somavarapu2005EffectOV,
  title={Effect of vitamin E TPGS on immune response to nasally delivered diphtheria toxoid loaded poly(caprolactone) microparticles.},
  author={Satyanarayana Somavarapu and Sreenivas Pandit and G Gradassi and M. C. de la Bandera and Easwaran Ravichandran and Oya H. Alpar},
  journal={International journal of pharmaceutics},
  year={2005},
  volume={298 2},
  pages={344-7}
}
The nasal mucosa has many advantages as a potential site for drug and vaccine delivery. The present study has sought to exploit this route of delivery using microparticles composed of D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) as a matrix material blended with poly(caprolactone) for nasal immunisation with diphtheria toxoid. Particles were prepared by a double emulsion method, followed by spray drying and the effect of TPGS on size, zeta potential, loading and release of… CONTINUE READING
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