Effect of vitamin C and L-NMMA on the inotropic response to dobutamine in patients with heart failure.

@article{Mak2005EffectOV,
  title={Effect of vitamin C and L-NMMA on the inotropic response to dobutamine in patients with heart failure.},
  author={S. Mak and C. Overgaard and G. Newton},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={289 6},
  pages={
          H2424-8
        }
}
The positive effect of vitamin C on left ventricular (LV) inotropic responses to dobutamine, observed in patients with preserved LV function, is lost in heart failure (HF). We tested the hypothesis that in HF, endogenous nitric oxide (NO) opposes the positive effect of vitamin C on adrenergically stimulated contractility by examining the effects of vitamin C on dobutamine responses during NO synthase inhibition. In 11 HF patients, a micromanometer-tipped catheter was inserted into the LV and an… Expand
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References

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Redox modulation of the inotropic response to dobutamine is impaired in patients with heart failure.
  • S. Mak, G. Newton
  • Medicine
  • American journal of physiology. Heart and circulatory physiology
  • 2004
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