Effect of viscous additives on drug absorption from the liver surface in rats using phenol red as a model.

@article{Nishida2000EffectOV,
  title={Effect of viscous additives on drug absorption from the liver surface in rats using phenol red as a model.},
  author={Koyo Nishida and Y Nakakoga and Naoyuki Sato and Shigeru Kawakami and Takahiro Mukai and Hitoshi Sasaki and Toshiyuki Sakaeda and Junzo Nakamura},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2000},
  volume={50 3},
  pages={397-402}
}
The purpose of this study is to obtain information that can be used to improve controlled release and residence time of drugs on the liver surface. Using carboxymethylcellulose sodium salt (CMC-Na) and polyvinyl alcohol (PVA), we examined the effect of viscous formulations on the absorption of phenol red as a model. In the presence of 3% CMC-Na or 15% PVA, the maximum plasma concentration of phenol red decreased after application to the rat liver surface using a cylindrical glass cell. The… CONTINUE READING

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