Effect of virus antibody on infection of mouse brain by Mount Elgon bat virus.

Abstract

Intranasal inoculation of mice aged 1-6 days with Mount Elgon but virus produced an acute brain infection and death of all the mice at 5-7 days after inoculation. Virus multiple in the olfactory bulbs and spread to the midbrain and then hindbrain, reaching titres of 10(9)-10(1)) plaque forming units/g of wet tissue. Fatal disease was prevented by… (More)

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