Effect of vigabatrin on epilepsy in mentally retarded patients: a 7-month follow-up study.

@article{Matilainen1988EffectOV,
  title={Effect of vigabatrin on epilepsy in mentally retarded patients: a 7-month follow-up study.},
  author={Riitta Matilainen and Asla Pitk{\"a}nen and T. Ruutiainen and Esa Mervaala and H. Sarlund and Paavo J. Riekkinen},
  journal={Neurology},
  year={1988},
  volume={38 5},
  pages={743-7}
}
We studied the antiepileptic potency of vigabatrin (gamma-vinyl GABA, GVG) as an open trial in a group of 36 mentally handicapped patients with drug-resistant epilepsy (30 had seizures of partial onset and 6 had primary generalized [PG] tonic-clonic convulsions). With this treatment, 13 (43%) of the patients with seizures of partial onset and 2 (33%) with PG had more than 50% reduction in seizure frequency. The antiepileptic effect appeared during the first month of therapy and continued… CONTINUE READING
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