Effect of vesicle composition and curvature on the dissociation of phosphatidic acid in small unilamellar vesicles--a 31P-NMR study.

@article{Swairjo1994EffectOV,
  title={Effect of vesicle composition and curvature on the dissociation of phosphatidic acid in small unilamellar vesicles--a 31P-NMR study.},
  author={Manal A. Swairjo and Barbara Ann Seaton and Mary Fedarko Roberts},
  journal={Biochimica et biophysica acta},
  year={1994},
  volume={1191 2},
  pages={
          354-61
        }
}
Sonicated small unilamellar vesicles (SUVs) containing phosphatidic acid (PA) give two PA 31P-NMR resonances corresponding to PA molecules in the inner and outer leaflets of the bilayer. This NMR differentiation between the two monolayers is not due to a pH gradient across the membrane but instead reflects differential packing in the inner and outer leaflets imposed by the highly curved SUV surface. The apparent pKa of the outer-leaflet PA increases with decreasing surface curvature and with… CONTINUE READING
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