Effect of vesamicol on the release of ATP from cortical synaptosomes.


The aim of the present experiments was to test whether vesamicol alters the evoked release of ATP from nerve terminals. Continuous or cumulative release of ATP evoked by 33 mM KC1 from rat cerebrocortical synaptosomes was largely calcium-dependent. Vesamicol interfered with release of ATP from synaptosomes depolarized with KCl (33 mM) in a dose-dependent… (More)