Effect of vehicles and esterification on the penetration and distribution of hypericin in the skin of hairless mice.


To study the in vivo penetration and skin distribution of hypericin, the compound (0.1%) was formulated in 10 different vehicles that are commonly used in pharmaceutical compounding, and applied on the skin of hairless mice for 4h. After application of hypericin in PEG ointment, white petrolatum or unguentum emulsificans, fluomicroscopic analysis of skin… (More)
DOI: 10.1016/j.pdpdt.2007.02.002


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