Effect of vasoactive intestinal peptide (VIP)‐related peptides on cholinergic neurogenic and direct mucus secretion in ferret trachea in vitro

@article{Liu1999EffectOV,
  title={Effect of vasoactive intestinal peptide (VIP)‐related peptides on cholinergic neurogenic and direct mucus secretion in ferret trachea in vitro},
  author={Y. Liu and A. Khawaja and D. Rogers},
  journal={British Journal of Pharmacology},
  year={1999},
  volume={128}
}
We investigated whether vasoactive intestinal peptide (VIP) and its related peptides, pituitary adenylate cyclase activating peptide (PACAP) and secretin, regulate cholinergic neural mucus secretion in ferret trachea in vitro, using 35SO4 as a mucus marker. We also studied the interaction between VIP and secretin on cholinergic mucus output. VIP (1 and 10 μM) increased secretion, whereas neither PACAP1–27, PACAP1–38 nor secretin (up to 10 μM) increased mucus output. In contrast, VIP, PACAP1–27… Expand
Vasoactive intestinal peptide stimulates mucus secretion, but nitric oxide has no effect on mucus secretion in the ferret trachea.
Motor control of airway goblet cells and glands.
  • D. Rogers
  • Biology, Medicine
  • Respiration physiology
  • 2001
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